The Impact of SARS-CoV-2 nsp14 Proofreading on Nucleoside Antiviral Activity: Insights from Genetic and Pharmacological Investigations
Ju-Yi Peng, Frederick C. Lahser, Christopher Warren, Xijing He, Edward J. Murray, Dai Wang
This study investigates how SARS-CoV-2 nsp14 proofreading affects nucleoside antiviral activity using genetic and pharmacological methods, finding that nsp14 attenuation increases sensitivity to nucleoside analogues.
bioRxiv · Jul 24, 2024 · PreprintMolecular Biology