The paper presents a multi-tissue sheep atlas identifying regulatory variants and their effects on molecular phenotypes, revealing allelic heterogeneity and evolutionary patterns.

bioRxiv · Nov 3, 2025 · PreprintGenomics

The Impact of SARS-CoV-2 nsp14 Proofreading on Nucleoside Antiviral Activity: Insights from Genetic and Pharmacological Investigations

Ju-Yi Peng, Frederick C. Lahser, Christopher Warren, Xijing He, Edward J. Murray, Dai Wang

This study investigates how SARS-CoV-2 nsp14 proofreading affects nucleoside antiviral activity using genetic and pharmacological methods, finding that nsp14 attenuation increases sensitivity to nucleoside analogues.

bioRxiv · Jul 24, 2024 · PreprintMolecular Biology

Transcriptional circuitry of NKX2-1 and SOX1 defines an unrecognized lineage subtype of small cell lung cancer

Ranran Kong, Ayushi S. Patel, Takashi Sato, Seungyeul Yoo, Li Bao, Abhilasha Sinha, Feng Jiang, Yang Tian, Maya Fridrikh, Shu‐Hui Liu, Jie Feng, Xijing He, Jiantao Jiang, Yuefeng Ma, Karina Grullon, , Hideo Watanabe

The paper identifies an epigenomic subtype of SCLC-A defined by NKX2-1 and SOX1 super-enhancers and their functional collaboration.

American Journal of Respiratory and Critical Care Medicine · Jul 18, 2022Peer-reviewedMolecular Biology