TDP-43 expression in the cytoplasm leads to early synaptic and mitochondrial abnormalities in an inducible mouse model of ALS/FTD
Florencia Vassallu, Milagros López, Florencia Lopez Ambrosioni, Juan Casal, Laura Romina Caltana, Lionel Muller Igaz
This study shows that cytoplasmic TDP-43 expression in mice leads to early synaptic and mitochondrial abnormalities linked to behavioral deficits in ALS/FTD.
Neurochemistry International · May 13, 2026Peer-reviewedNeuroscience