Lionel Muller Igaz

This study shows that cytoplasmic TDP-43 expression in mice leads to early synaptic and mitochondrial abnormalities linked to behavioral deficits in ALS/FTD.

This study examines region-specific glial activation and Aquaporin-4 dysregulation in two mouse models of TDP-43 proteinopathies, revealing distinct neuroinflammatory patterns and potential implications for disease mechanisms.

This study uses a C. elegans model to show that cytoplasmic TDP-43 causes early functional impairments in serotonergic neurons without neurodegeneration.

This study identifies persistent extra-motor behavioural deficits in rNLS8 TDP-43 mice, linked to synaptic gene expression and splicing changes that persist even after motor recovery.