Vascular-water-exchange MRI (VEXI) enables the detection of subtle BBB breakdown in Alzheimer's disease without MRI contrast agent
Yifan Zhang, Yue Wang, Zhaoqing Li, Zejun Wang, Juange Cheng, Xiaoyan Bai, Yi‐Cheng Hsu, Yi Sun, Shiping Li, Jiong Shi, Binbin Sui, Ruiliang Bai
This study introduces VEXI, a contrast-agent-free MRI method to detect BBB breakdown in AD, showing increased permeability in MCI and AD patients, specifically in hippocampus, orbital frontal cortex, and thalamus, correlated with cognitive impairment.
bioRxiv · Sep 27, 2022 · PreprintNeuroscience