NeurosciencebioRxivPreprint
Vascular-water-exchange MRI (VEXI) enables the detection of subtle BBB breakdown in Alzheimer's disease without MRI contrast agent
Yifan Zhang, Yue Wang, Zhaoqing Li…·Ruiliang Bai
This study introduces VEXI, a contrast-agent-free MRI method to detect BBB breakdown in AD, showing increased permeability in MCI and AD patients, specifically in hippocampus, orbital frontal cortex, and thalamus, correlated with cognitive impairment.