Male-specific analgesic effects of minocycline in sickle cell disease are mediated by microglia and the microbiome
Juanna M. John, Zulmary Manjarres, Nurfatihah I. Zulkifly, Ashley N. Plumb, McKenna L. Pratt, Katelyn E. Sadler
This study shows that minocycline reduces chronic pain in male sickle cell disease mice via microglia and microbiome changes, but not in females.
Pain · May 26, 2026Peer-reviewedNeuroscience