The modification of DNA with indole-linked nucleotides alters its sensitivity to enzymatic cleavage
Lingala Suresh, Anastasiia Fisiuk, Michelle Stephen, Raja Mohanrao, Judah Klingsberg, Simon Vecchioni, Ealonah S Volvovitz, S. P. Rozhkov, Prabodhika R. Mallikaratchy
This paper modifies DNA with indole-linked nucleotides, altering its conformation and sensitivity to enzymatic cleavage, with implications for antisense therapeutics and small molecule screening.
bioRxiv · Jan 26, 2025 · PreprintBiochemistry