Prabodhika R. Mallikaratchy

This paper introduces a ligand-guided selection method to discover aptamers specific to GPCRs in their native membrane context, showing they bind selectively to cell-surface receptors and induce internalization.

This paper designs and characterizes bivalent aptamer assemblies targeting CD19 and CD20, showing enhanced binding and functional properties for B-cell malignancies.

This paper modifies DNA with indole-linked nucleotides, altering its conformation and sensitivity to enzymatic cleavage, with implications for antisense therapeutics and small molecule screening.