Hexose-6-phosphate dehydrogenase deficiency disrupts hepatic fatty acid homeostasis and induces triglyceride accumulation
Gabrielé Sakalauskaite, Sophie Ebert, Julien Arthur Allard, Michael Zogg, Isabel Meister, Julia Birk, Alexander Schmidt, Jamal Bouitbir, Alex Odermatt
This study shows that H6PD deficiency in mice leads to increased hepatic triglycerides and lipid accumulation, linking NADPH availability to fatty acid homeostasis.
bioRxiv · Sep 10, 2026 · PreprintSystems Biology