Alex Odermatt

This study shows that H6PD deficiency in mice leads to increased hepatic triglycerides and lipid accumulation, linking NADPH availability to fatty acid homeostasis.

The paper identifies gut bacteria-produced metabolites that inhibit HSD11B2, altering cortisol signaling and linking microbiome activity to blood pressure regulation.

This study shows that sleeve gastrectomy reduces circulating active/inactive glucocorticoid ratios and improves glucose tolerance in mice by increasing renal HSD11B2 activity.

The paper investigates how ApoE4 affects intracellular trafficking and iron homeostasis in human brain endothelial cells derived from iPSCs, showing altered endosomal organization and iron levels.

This study identifies 11beta-HSD1 as a driver of myofibroblast differentiation in CKD, showing its inhibition reduces fibrosis and improves renal function.

Paraffin histology, multiplex immunofluorescence and MALDI imaging work on blood-brain barrier organoids; an AI apoptosis detector on hematoxylin-eosin slides (F1 0.817 vs pathologists) tracked staurosporine dose responses.

PanScreen assesses off-target liabilities of small molecules using structure-based modeling and deep learning, offering accurate predictions and insights into potential modes of action.

This study identifies androglobin (Adgb) as essential for male fertility in mice, showing its role in spermatogenesis and flagellum formation through interactions with Sept10.

The paper develops an in silico workflow to predict molecular targets of natural products and identifies four new targets for dihydrochalcones.