Pharmacology & ToxicologybioRxivPreprint
Peptide Sequence Determines the Efficacy of Single-Dose AAV-Vectorized GLP-1R Agonists in Diet-Induced Obese Mice
Donghyung Lee, Krister Bokvist, Greg Nachtrab…·David Woldbye
This study evaluates the efficacy of different GLP-1R agonist peptides delivered via AAV vectors in diet-induced obese mice, finding that Ex4 and Ex4-Fc variants show significant weight loss and metabolic improvements compared to GLP-1 and Gly8.
DOI 10.64898/2026.11.08.759712