TACR3 variant confers resilience to aging and Alzheimer's disease
Nicolas Ruffini, Florian Udo Fischer, Robert Subirana Slotos, Julia Goschke, Leon Scholz, Kristel Knaepen, Stefan Hüttelmaier, Helen Morrison, Theresa Steffan, Ann-Sophie Pabst, Jennifer Winter, Bernhard Baier, Andreas Mierau, Harald Binder, Alexander E. Drzezga, , the Frontotemporal Lobar Degeneration Neuroimaging Initiative
This study identifies the TACR3 variant rs2765 as protective against age- and Alzheimer's-related cognitive decline, showing slower cognitive decline and younger epigenetic age in carriers.
medRxiv · Jun 8, 2026 · PreprintGenetic & Genomic Medicine