Optogenetic cross-linking of the actin cytoskeleton using DARPins
Julia R. Ivanova, Ann-Cathrin Boettinger, Andreas Fink, Julia Köberle, Karim Ajmail, Amelie S. Benk, Dimitris Missirlis, Joachim Pius Spatz
This paper introduces an optogenetic system using DARPins to reversibly control actin cross-linking in living cells, showing inhibition of cell traction forces upon light activation.
bioRxiv · May 22, 2026 · PreprintCell Biology