Global architecture of the nucleus in single cells by DNA seqFISH+ and multiplexed immunofluorescence
Yodai Takei, Jina Yun, Shiwei Zheng, Noah Ollikainen, Nico G Pierson, Jonathan A. White, Sheel Shah, Julian Thomassie, Shengbao Suo, Chee-Huat Linus Eng, Mitchell Guttman, Guo‐Cheng Yuan, Long Cai
The paper maps chromatin states, DNA loci, and gene expression in single mouse embryonic stem cells using DNA seqFISH+ and immunofluorescence, revealing nuclear zones and subpopulations with distinct chromatin features.
Nature · Jan 27, 2021Peer-reviewedSystems Biology