Benchmarking Boltz-2 for Screening of Therapeutic Antibody-Antigen Interactions
Alexandra Fieux-Castagnet, Julian Waton, Alina Glukhonemykh, Eric Snow, Roshini Ashokkumar, Jess Fleming, David Champagne, Thomas Devenyns, Alex Peluffo, Christoforos Anagnostopoulos
The paper benchmarks Boltz-2 for screening therapeutic antibody-antigen interactions, finding weak but above-chance discrimination and limited benefit from extensive sampling.
bioRxiv · May 14, 2026 · PreprintBioinformatics