Accurate Prediction of ecDNA in Interphase Cancer Cells using Deep Neural Networks
Utkrisht Rajkumar, Gino Prasad, Ellis J. Curtis, Ivy Tsz-Lo Wong, Xiaowei Yan, Shu Zhang, Lotte Brückner, Kristen M. Turner, Julie Wiese, Justin Wahl, Sihan Wu, Jessica Theißen, Matthias Fischer, Howard Y. Chang, Anton George Henssen, , Vineet Bafna
The paper introduces interSeg, a deep learning tool that accurately predicts oncogene amplification status from interphase FISH images, achieving high accuracy in detecting ecDNA and chromosomal amplifications.
bioRxiv · Jun 23, 2025 · PreprintCancer Biology