Sihan Wu

This study identifies cis and trans regulatory mechanisms governing ecDNA segregation, showing H3K27ac and bromodomain proteins mediate interactions, while inactive Pol II facilitates attachment.

This study shows that the cGAS-STING pathway suppresses ecDNA-driven tumorigenesis by detecting ecDNA fragments and restricting their formation.

The paper introduces ec3D, a method to reconstruct 3D structures of ecDNA from Hi-C data, revealing spherical configurations and unique long-range interactions in cancer.

This study shows ecDNA-driven oncogene super-expressors create an immunoevasive tumor microenvironment in PDAC by promoting myCAF expansion and suppressing T cell infiltration.

This study investigates the role of small extrachromosomal circular DNA (eccDNA) in colorectal cancer, finding that it contributes to gene expression, immune cell recruitment, and poor patient outcomes.

The paper introduces interSeg, a deep learning tool that accurately predicts oncogene amplification status from interphase FISH images, achieving high accuracy in detecting ecDNA and chromosomal amplifications.

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

The paper shows that ecDNA interactomes are shaped by nascent RNA, with PVT1 and MYC ecDNA using noncoding RNA for trans-activation, while EGFR ecDNA is less effective due to efficient splicing.

The paper investigates the development and evolution of extrachromosomal DNA (ecDNA) in Barrett's esophagus patients progressing to esophageal adenocarcinoma, finding ecDNA is strongly associated with cancer progression and enriched for oncogenes and immunomodulatory genes.