Phage-encoded CasPRs transcriptionally silence diverse CRISPR-Cas systems
Edith M Sanderson, Julieta Peralta, Sam Nouwens, Luke Oriolt, Victoria M. Hayes, Brett K. Kaiser, Alexander J. Meeske
The paper identifies CasPRs, DNA-binding anti-CRISPRs that silence CRISPR-Cas systems by blocking transcription, and shows their activity against different CRISPR types.
bioRxiv · Feb 23, 2026 · PreprintMicrobiology