SIRPγ modulates effector differentiation of human CD8 T Cells under suboptimal TCR stimulation: implications for immune homeostasis and autoimmunity
Megan Morse, Xanthie Rodriguez, Erika DeLaRosa, Susana G. Rodriguez, Juma Shanil, Sushmita Sinha
This study shows that SIRPγ reduces effector differentiation of CD8 T cells under weak TCR signals, linking its expression to immune homeostasis and autoimmunity risk.
bioRxiv · Jul 9, 2025 · PreprintImmunology