T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type-1 cells
Josep Garnica, Patricia Sole, Jun Yamanouchi, Joel Moro, Debajyoti Mondal, Cesar Fandos, Pau Serra, Pere Santamaria
The paper investigates the epigenetic mechanisms enabling T-follicular helper cells to transdifferentiate into TR1 cells, finding that TR1 gene programs are pre-established in TFH cells.
bioRxiv · May 17, 2024Immunology