Josep Garnica

Evaluating cell type annotations in single-cell omics in the absence of ground truth

This paper introduces ISC, a framework to evaluate cell type annotations in single-cell RNA-seq without ground truth, revealing reproducibility gaps and enabling tool benchmarking.

KLRG1 identifies circulating cytotoxic CD4 T cells with selective anti-tumor function in human cancer

This study identifies KLRG1 as a marker for cytotoxic CD4 T cells in cancer patients and shows their anti-tumor function and regulation by IL-6.

T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type-1 cells

The paper investigates the epigenetic mechanisms enabling T-follicular helper cells to transdifferentiate into TR1 cells, finding that TR1 gene programs are pre-established in TFH cells.