Circadian phosphotimer generates time cues through PER dimerization-mediated trans-phosphorylation
Kwangjun Lee, Jiyoung Park, Junghyun Lee, Jun Ho, Christian I. Hong, Sookkyung Lim, Choogon Lee
The paper shows that PER dimerization-mediated trans-phosphorylation generates time cues for circadian rhythms, and disrupts it shortens the circadian period and advances sleep cycles in mice.
bioRxiv · Oct 1, 2025 · PreprintNeuroscience