Targeted Degradation of METTL3 Against Acute Myeloid Leukemia and Gastric Cancer.
Kyubin Hwang, Juhyeon Bae, Yoo-Lim Jhe, Jungmin Kim, Jae-Ho Cheong, Ha-Soon Choi, Taebo Sim
This study develops KH12, a METTL3 degrader, showing potent anti-leukemia and anti-gastric cancer effects through m6A-dependent and -independent mechanisms.
bioRxiv · Feb 2, 2024Biochemistry