Distinct roles of the two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA Pol II transcription elongation
Zhuanzhuan Che, Xiaoxu Liu, Qian Dai, Ke Fang, Chenghao Guo, Junjie Yue, Haitong Fang, Peng Xie, Zhuojuan Luo, Chengqi Lin
This study shows AFF1 and AFF4 have distinct roles in RNA Pol II transcription elongation, with AFF1 upstream and AFF4 downstream of TSS, and they function antagonistically to regulate transcription.
Journal of Molecular Cell Biology · Jul 31, 2023Peer-reviewedGenomics