Haitong Fang

The paper uses single-cell multi-omics to study early cardiac lineage specification in mouse embryos, identifying key transcription factors and regulatory networks.

This study shows AFF1 and AFF4 have distinct roles in RNA Pol II transcription elongation, with AFF1 upstream and AFF4 downstream of TSS, and they function antagonistically to regulate transcription.

This study identifies RNF219 as an interacting partner of the CCR4-NOT deadenylase complex, showing its role in regulating RNA stability and ES cell differentiation.