Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment
Mengqiao Cui, Xiaoyuan Pan, Zhijie Fan, Shulin Wu, Ran Ji, Xianlei Wang, Xiangxi Kong, Zhou Wu, Lingzhen Song, Weiyi Song, Junxia Yang, Hongjie Zhang, Hongxing Zhang, Hai‐Lei Ding, Jun‐Li Cao
The paper identifies S1P/S1PR1 signaling as a key determinant of vulnerability to chronic pain-related memory impairment in mice, showing that modulating this pathway can alter susceptibility and rescue memory deficits.
eLife · Dec 19, 2024Peer-reviewedNeuroscience