Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment
Mengqiao Cui, Xiaoyuan Pan, Zhijie Fan…·Jun‐Li Cao
The paper identifies S1P/S1PR1 signaling as a key determinant of vulnerability to chronic pain-related memory impairment in mice, showing that modulating this pathway can alter susceptibility and rescue memory deficits.