Identification and characterization of a novel exo-(N-)glycanase activity of NGLY1 on ENGase-digested N-GlcNAc proteins in vitro
Yilin Ye, Xinrong Lu, Shaoxian Lyu, Yuxin Zhang, Qiange Lin, Xin Qian, Junyou Lin, Zhijian Yu, Li Chen, Guiqin Sun
This study identifies and characterizes a novel exo-(N-)glycanase activity of NGLY1 on N-GlcNAc proteins in vitro, expanding its functional repertoire and linking it to clinical features of NGLY1-CDDG.
bioRxiv · Aug 21, 2025 · PreprintBiochemistry