High Throughput Characterization of V(D)J Recombination Signal Sequences Redefines the Consensus Sequence
Walker Hoolehan, Justin C. Harris, Jennifer N. Byrum, Karla K. Rodgers
The paper develops a high-throughput assay to analyze V(D)J recombination signal sequences (RSSs) and finds RAG1/2 activity is influenced by DNA structural features rather than strict sequence conservation.
bioRxiv · Dec 3, 2021 · PreprintMolecular Biology