Spatial remodeling of bone marrow architecture defines tissue-state signatures of disease activity and therapeutic response in myelodysplastic neoplasms
Ryan Nachman, Aleksandra Kopacz, Caitlin Unkenholz, Jian Chai, Arvin Ruiz, Itzel Valencia, Jeanne Jiang, Fabio Socciarelli, Jiwoon Park, Christopher E. Mason, Ling Zhang, David Andrew Sallman, Gail J. Roboz, Pinkal M. Desai, Justin Kaner, , Sanjay S. Patel
This study uses spatial imaging to identify architectural changes in bone marrow that predict disease activity and response to therapy in myelodysplastic neoplasms.
Leukemia · Jun 30, 2026Peer-reviewedPathology