Author

Itzel Valencia

Weill Cornell MedicineORCID 0000-0002-7450-9307Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Pathology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:imaging· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Caitlin UnkenholziD· 2 shared Giorgio InghiramiiD· 2 shared Julia Turbiner GeyeriD· 2 shared Sanjay S. PateliD· 2 shared Aida Akaeva· 1 shared Aleksandr SarachakoviD· 1 shared Aleksandra KopacziD· 1 shared Alexander BagaeviD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPathology

Caitlin UnkenholzORCID

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Author profile →

3 papers

Recent·Most cited

Spatial remodeling of bone marrow architecture defines tissue-state signatures of disease activity and therapeutic response in myelodysplastic neoplasms

Ryan Nachman, Aleksandra Kopacz, Caitlin Unkenholz, Jian Chai, Arvin Ruiz, Itzel Valencia, Jeanne Jiang, Fabio Socciarelli, Jiwoon Park, Christopher E. Mason, Ling Zhang, David Andrew Sallman, Gail J. Roboz, Pinkal M. Desai, Justin Kaner, , Sanjay S. Patel

This study uses spatial imaging to identify architectural changes in bone marrow that predict disease activity and response to therapy in myelodysplastic neoplasms.

Leukemia · Jun 30, 2026Peer-reviewedPathology

sctrial: Participant-Level Differential Analysis for Longitudinal Single-Cell Experiments

Priyanka Vasanthakumari, Itzel Valencia, Maryam Ranjpour Aghmiouni, Bryan Magana, Mohamed Abbas Omar

sctrial provides participant-level differential analysis for longitudinal single-cell experiments, reducing pseudoreplication-driven signal inflation and improving reliability of biological interpretations.

bioRxiv · Apr 6, 2026 · PreprintBioinformatics

Single Cell Resolution Spatial Mapping of Human Hematopoiesis Reveals Aging-Associated Topographic Remodeling

Aleksandr Sarachakov, Arina Varlamova, Viktor Svekolkin, Ilia Galkin, Itzel Valencia, Caitlin Unkenholz, Tania Pannellini, Aida Akaeva, Sofia Smirnova, Pavel Ovcharov, Margarita Polyakova, D Tabakov, Ekaterina Postovalova, Isha Sethi, Nara Shin, , Sanjay S. Patel

This study maps human hematopoiesis at single-cell resolution, revealing aging-associated topographic remodeling in bone marrow.

bioRxiv · Apr 28, 2023 · PreprintSystems Biology