Author

Ryan Nachman

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Shahin RafiiiD· 3 shared Aleksandra KopacziD· 1 shared Amy ChadburniD· 1 shared Anna Ada DattoliiD· 1 shared Arvin Ruiz· 1 shared Brad Pearson· 1 shared Bradley Pearson· 1 shared Caitlin UnkenholziD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

Shahin RafiiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Generation of hypoimmunogenic gastric insulin-secreting organoids

Anna Ada Dattoli, Matthew E. Brown, Bradley Pearson, Zachary Feinstein, Ying Lan, Vasumati Polavarapu, Max Zhou, Ryan Nachman, Yosip Kelemen, Shahin Rafii, Rémi J. Creusot, Todd M. Brusko, Qiao Zhou, Xiaofeng Huang

This study generates hypoimmunogenic gastric insulin-secreting organoids (GINS) and shows PD-L1 engineering improves their survival under immune challenge.

bioRxiv · Jul 13, 2026 · PreprintImmunology

Spatial remodeling of bone marrow architecture defines tissue-state signatures of disease activity and therapeutic response in myelodysplastic neoplasms

Ryan Nachman, Aleksandra Kopacz, Caitlin Unkenholz, Jian Chai, Arvin Ruiz, Itzel Valencia, Jeanne Jiang, Fabio Socciarelli, Jiwoon Park, Christopher E. Mason, Ling Zhang, David Andrew Sallman, Gail J. Roboz, Pinkal M. Desai, Justin Kaner, , Sanjay S. Patel

This study uses spatial imaging to identify architectural changes in bone marrow that predict disease activity and response to therapy in myelodysplastic neoplasms.

Leukemia · Jun 30, 2026Peer-reviewedPathology

Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage

Ying Liu, Tansol Choi, Brad Pearson, Ryan Nachman, Whitney Woo, Na Xu, Ryan P. Schreiner, Romulo Hurtado, Marco Seandel, Shahin Rafii, Todd Evans

This study shows that SPRY4-ERK signaling acts as a checkpoint to restore spermatogenesis after germline stem cell damage, with its loss leading to impaired regeneration and fertility.

Biology of Reproduction · Mar 19, 2026Peer-reviewedCell Biology