MAIT cells exacerbate liver fibrosis by downsizing the intrahepatic regulatory T cell compartment
Nicole I. Wang, Valeryia Shydlouskaya, K R Reid, Agetha Mahendran, Angela Schincaglia, Brian A. Keller, Shereen Q Zia, Ahmad Reza Movasseghi, Julius Haruna, Dale Ian Godfrey, S. M. Mansour Haeryfar
This study identifies MAIT cells as early drivers of liver fibrosis by reducing regulatory T cell numbers and function, revealing a novel MAIT-Treg axis as a potential therapeutic target.
bioRxiv · Apr 19, 2026 · PreprintImmunology