Dale Ian Godfrey

The paper develops a nanobody targeting MR1-5-OP-RU complexes and demonstrates its ability to modulate MAIT cell responses and act as a bispecific engager.

This study identifies γδ T cell infiltration in SCLC and shows their anti-tumor activity, suggesting they could be therapeutic targets.

The paper identifies a conserved TCR motif recognizing mycobacterial lipids presented by CD1c, showing higher frequencies in TB-endemic regions and providing a cryo-EM structure of the interaction.

This study identifies MAIT cells as early drivers of liver fibrosis by reducing regulatory T cell numbers and function, revealing a novel MAIT-Treg axis as a potential therapeutic target.

This study identifies a mechanism by which CD1c presents two lipids simultaneously, with bulky headgroups oriented sideways, enabling autoreactive TCR recognition.

This study shows that purinergic signaling via ARTC2 and P2RX7 regulates the survival and function of unconventional T cells, affecting IFN-γ and IL-4 production.