AI-Driven Design of Nanobinders Targeting the TSLPR Heterodimer Interface to Suppress Type 2 Inflammatory Signaling
Woo‐Chan Ahn, Min-Jung Son, Jae-Rin Kim, Seong-Ryeong Go, J Y Kang, Junsoo Park, Younghoon Lee, S H Lee, Jae‐Joong Kim, Juyeon Jung, Eui‐Jeon Woo, Young‐Joo Jeon, K S Park
This paper designs AI-driven nanobinders targeting the TSLPR-IL-7R heterodimer interface to suppress type 2 inflammatory signaling, showing that geometric mimicry of the native cytokine is more effective than affinity alone.
bioRxiv · Jul 22, 2026 · PreprintBiochemistry