Mechanistic insights into volatile anesthetic modulation of K2P channels
A. Wague, T. T. Joseph, K. A. Woll, W. Bu, K. A. Vaidya, N. V. Bhanu, B. A. Garcia, C. M. Nimigean, R. G. Eckenhoff, P. M. Riegelhaupt
This study identifies a volatile anesthetic binding site in TREK1 K2P channels and shows its role in modulating channel activity through molecular dynamics and mutagenesis.
bioRxiv · Jun 10, 2020Pharmacology & Toxicology