Author

T. T. Joseph

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

G. Brannigan· 2 shared R. G. Eckenhoff· 2 shared W. Bu· 2 shared A. Wague· 1 shared B. A. Garcia· 1 shared B. Deng· 1 shared C. M. Nimigean· 1 shared E. Santiago-McRae· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

G. Brannigan

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3 papers

Recent·Most cited

Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)

T. T. Joseph, W. Bu, O. Haji-Ghassemi, Y. S. Chen, K. Woll, P. D. Allen, G. Brannigan, F. van Petegem, R. G. Eckenhoff

This study shows propofol directly binds and inhibits RyR1, reducing Ca2+ release and potentially protecting against malignant hyperthermia.

bioRxiv · Jan 10, 2024 · PreprintPharmacology & Toxicology

Structural mechanism of leaflet-specific phospholipid modulation of a pentameric ligand-gated ion channel

J. T. Petroff, N. M. Dietzen, E. Santiago-McRae, B. Deng, M. S. Washington, L. J. Chen, K. T. Moreland, Z. Deng, M. Rau, J. A. Fitzpatrick, P. Yuan, T. T. Joseph, J. Henin, G. Brannigan, W. W. Cheng

The paper shows phosphatidylglycerol stabilizes the open state of ELIC by binding to a specific outer leaflet site, identified through structural and functional analyses.

bioRxiv · Jun 7, 2022 · PreprintBiophysics

Mechanistic insights into volatile anesthetic modulation of K2P channels

A. Wague, T. T. Joseph, K. A. Woll, W. Bu, K. A. Vaidya, N. V. Bhanu, B. A. Garcia, C. M. Nimigean, R. G. Eckenhoff, P. M. Riegelhaupt

This study identifies a volatile anesthetic binding site in TREK1 K2P channels and shows its role in modulating channel activity through molecular dynamics and mutagenesis.

bioRxiv · Jun 10, 2020Pharmacology & Toxicology