Author

C. M. Nimigean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:fungi (other)· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Accardi· 1 shared A. Di Lorenzo· 1 shared A. Raczkowski· 1 shared A. Tong· 1 shared A. Wague· 1 shared B. A. Garcia· 1 shared B. Carragher· 1 shared B. Malone· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

A. Accardi

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Author profile →

4 papers

Recent·Most cited

Time-resolved cryoEM using Spotiton

V. P. Dandey, W. C. Budell, H. Wei, D. Bobe, K. Maruthi, M. Kopylov, E. T. Eng, P. A. Kahn, J. E. Hinshaw, N. Kundu, C. M. Nimigean, C. Fan, N. Sukomon, S. Darst, R. Saecker, , B. Carragher

The paper introduces a method for preparing cryoEM grids to study short-lived molecular states by rapidly dispensing sample drops and vitrifying them.

Microscopy and Microanalysis · Jul 30, 2020Peer-reviewedBiophysics

Mechanistic insights into volatile anesthetic modulation of K2P channels

A. Wague, T. T. Joseph, K. A. Woll, W. Bu, K. A. Vaidya, N. V. Bhanu, B. A. Garcia, C. M. Nimigean, R. G. Eckenhoff, P. M. Riegelhaupt

This study identifies a volatile anesthetic binding site in TREK1 K2P channels and shows its role in modulating channel activity through molecular dynamics and mutagenesis.

bioRxiv · Jun 10, 2020Pharmacology & Toxicology

Direct Binding of Phosphatidylglycerol at Specific Sites Modulates Desensitization of a Pentameric Ligand-Gated Ion Channel

A. Tong, J. T. Petroff, F.-F. Hsu, P. A. Schmidpeter, C. M. Nimigean, L. Sharp, G. Brannigan, W. W. Cheng

The paper shows that phosphatidylglycerol binds to and stabilizes the pentameric ligand-gated ion channel ELIC, reducing desensitization.

bioRxiv · Aug 7, 2019Biophysics

Cryo-EM structures reveal bilayer remodeling during Ca2+ activation of a TMEM16 scramblase

M. E. Falzone, J. Rheinberger, B.-C. Lee, T. Peyear, L. Sasset, A. Raczkowski, E. Eng, A. Di Lorenzo, O. S. Andersen, C. M. Nimigean, A. Accardi

The paper presents cryo-EM structures of a fungal TMEM16 scramblase showing Ca2+-induced conformational changes and membrane reorganization.

bioRxiv · Nov 5, 2018Biochemistry