The skin environment controls local dendritic cell differentiation and function through innate IL-13
J. U. Mayer, O. Lamiable, K. L. Hilligan, J. S. Chandler, S. I. Old, D. A. Eccles, J. Yang, G. R. Webb, R. G. Domingues, L. Munoz-Erazo, K. A. Wakelin, E. J. Hyde, S.-C. Tang, S. C. Chappell, C. R. Mackay, , F. Ronchese
This study shows that IL-13 signaling via STAT6 and KLF4 controls dermal DC2 differentiation and function, shaping a non-inflammatory, pro-allergic skin environment.
bioRxiv · Jan 5, 2021Immunology