This study shows that GPR41/43 receptors regulate blood pressure by maintaining gut barrier integrity and preventing renal inflammation through TLR4 signaling.

bioRxiv · Mar 20, 2023Physiology

Maternal diet and gut microbiota influence predisposition to cardiovascular disease in the offspring

H. A. Jama, M. I. Dona, E. Dinakis, M. Nakai, M. R. Paterson, W. Shihata, C. Krstevski, C. D. Cohen, K. Weeks, G. E. Farrugia, C. Johnson, E. Salimova, D. Donner, H. Kiriazis, H. Kaipananickal, , F. Z. Marques

The paper shows that maternal fibre intake during pregnancy influences offspring cardiovascular health by shaping the gut microbiome and inducing epigenetic changes in the offspring's heart.

bioRxiv · Mar 12, 2022Microbiology

The skin environment controls local dendritic cell differentiation and function through innate IL-13

J. U. Mayer, O. Lamiable, K. L. Hilligan, J. S. Chandler, S. I. Old, D. A. Eccles, J. Yang, G. R. Webb, R. G. Domingues, L. Munoz-Erazo, K. A. Wakelin, E. J. Hyde, S.-C. Tang, S. C. Chappell, C. R. Mackay, , F. Ronchese

This study shows that IL-13 signaling via STAT6 and KLF4 controls dermal DC2 differentiation and function, shaping a non-inflammatory, pro-allergic skin environment.

bioRxiv · Jan 5, 2021Immunology

Identification of A Disintegrin and Metalloproteinase 9 domain (ADAM9) required in the early stages of encephalomyocarditis virus infection

L. E. Bazzone, M. King, C. R. MacKay, P. P. Kyawe, P. Meraner, D. Lindstrom, J. Rojas-Quintero, C. A. Owen, J. P. Wang, A. L. Brass, E. A. Kurt-Jones, R. W. Finberg

This study identifies ADAM9 as a host factor required for early stages of EMCV infection using CRISPR-Cas9 screening, showing resistance in ADAM9 knockout cells.

bioRxiv · Dec 9, 2018Microbiology