K. L. Hilligan

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

This study shows that pre-existing lung inflammation reduces SARS-CoV-2 replication by activating innate immune pathways, highlighting the role of the inflammatory microenvironment in controlling viral infection.

Pre-existing interferon gamma conditions the lung to mediate early control of SARS-CoV-2

This study shows that pre-existing IFN-gamma responses from bacterial infection reduce SARS-CoV-2 viral loads in the lungs and protect against disease in mice.

Helminth exposure protects against murine SARS-CoV-2 infection through macrophage dependent T cell activation

This study shows that prior helminth infection reduces SARS-CoV-2 viral loads in mice by enhancing CD8+ T cell responses through macrophage-dependent mechanisms.

Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infection

This study evaluates the antiviral and inflammatory effects of 25-hydroxycholesterol and its metabolite in murine SARS-CoV-2 models, finding no significant antiviral activity and potential pro-injury effects.

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

This study shows that intravenous BCG vaccination protects mice from lethal SARS-CoV-2 infection by altering pulmonary myeloid cell function and reducing immunopathology.

The skin environment controls local dendritic cell differentiation and function through innate IL-13

This study shows that IL-13 signaling via STAT6 and KLF4 controls dermal DC2 differentiation and function, shaping a non-inflammatory, pro-allergic skin environment.