The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
K. Kakihara, K. Asamizu, K. Moritsugu, M. Kubo, T. Kitaguchi, A. Endo, A. Kidera, M. Ikeguchi, A. Kato, M. Komada, T. Fukushima
This study identifies an autoinhibitory WW-like domain in USP8 that regulates its enzyme activity and links its release to Cushings disease.
bioRxiv · May 31, 2021Biochemistry