Author

A. Kidera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:structural biology· 2 Organism:virus· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. Moritsugu· 5 shared M. Ikeguchi· 4 shared M. Komada· 2 shared T. Ekimoto· 2 shared T. Fukushima· 2 shared A. Endo· 1 shared A. Kato· 1 shared B. Lestari· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersBiophysics

K. Moritsugu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The placental protein NRK promotes cell death through its plasma membrane-localizing CNH domain

B. Lestari, K. Soda, K. Moritsugu, A. Kidera, Y. Suenaga, Y. Hippo, E. Meiyanto, M. Komada, M. S. H. Wahyuningsih, T. Fukushima

This study identifies the CNH domain of NRK as a key mediator of cell death by localizing to the plasma membrane via phospholipid binding.

bioRxiv · Dec 27, 2023 · PreprintCell Biology

Binding and unbinding pathways of peptide substrate on SARS-CoV-2 3CL protease

K. Moritsugu, T. Ekimoto, M. Ikeguchi, A. Kidera

This study investigates the binding and unbinding pathways of an eight-residue peptide to SARS-CoV-2 3CL protease using weighted ensemble simulations, revealing the sequential formation of hydrogen bonds during the binding process.

bioRxiv · Jun 8, 2022Biophysics

Allosteric regulation of 3CL protease of SARS-CoV-2 and SARS-CoV observed in the crystal structure ensemble

A. Kidera, K. Moritsugu, T. Ekimoto, M. Ikeguchi

The paper analyzes the structural dynamics of SARS-CoV-2 and SARS-CoV 3CLpro using crystal structures to understand allosteric regulation and ligand binding effects.

bioRxiv · Aug 29, 2021Biophysics

The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

K. Kakihara, K. Asamizu, K. Moritsugu, M. Kubo, T. Kitaguchi, A. Endo, A. Kidera, M. Ikeguchi, A. Kato, M. Komada, T. Fukushima

This study identifies an autoinhibitory WW-like domain in USP8 that regulates its enzyme activity and links its release to Cushings disease.

bioRxiv · May 31, 2021Biochemistry

Energetics and Conformational Pathways of Functional Rotation in the Multidrug Transporter AcrB

Y. Matsunaga, T. Yamane, T. Terada, K. Moritsugu, H. Fujisaki, S. Murakami, M. Ikeguchi, A. Kidera

This study calculates the minimum free energy pathway of functional rotation in AcrB, linking it to proton translocation and drug transport at the atomic level.

bioRxiv · Aug 8, 2017Biophysics