Complementary biological and computational approaches identify distinct mechanisms of chlorpyrifos versus chlorpyrifos oxon induced dopaminergic neurotoxicity
S. R. Sammi, T. Syeda, K. Conrow, M. Leung, J. Cannon
This study compares chlorpyrifos and its oxon metabolite, showing CPF causes irreversible dopaminergic neurotoxicity through mitochondrial and metabolic effects, while CPF oxon does not.
bioRxiv · Jul 15, 2022Pharmacology & Toxicology