Disrupted in Renal Carcinoma 3 (DIRC3) impacts malignant phenotype and IGFBP5/IGF-1/Akt signaling axis in differentiated thyroid cancer.
P. T. Wysocki, K. Czubak, A. A. Marusiak, M. Kolanowska, D. Nowis
This study shows DIRC3 downregulation in thyroid cancer promotes migration, reduces apoptosis, and enhances Akt signaling through the IGFBP5/IGF-1 axis.
bioRxiv · Jan 24, 2023 · PreprintCancer Biology