D. Nowis

SARS-CoV-2 and its ORF3a, E and M viroporins activate inflammasome in human macrophages and induce of IL-1α in pulmonary epithelial and endothelial cells

This study shows SARS-CoV-2 viroporins ORF3a, E, and M activate inflammasomes in macrophages and induce IL-1α release in pulmonary epithelial and endothelial cells, contributing to immunothrombosis in COVID-19.

Trinucleotide mRNA cap analog N6-benzylated at the site of posttranscriptional m6Am mark facilitates mRNA purification and confers superior translational properties in vitro and in vivo

This paper introduces a modified mRNA cap analog, AvantCap, which improves mRNA purification and translational efficiency in vitro and in vivo.

Disrupted in Renal Carcinoma 3 (DIRC3) impacts malignant phenotype and IGFBP5/IGF-1/Akt signaling axis in differentiated thyroid cancer.

This study shows DIRC3 downregulation in thyroid cancer promotes migration, reduces apoptosis, and enhances Akt signaling through the IGFBP5/IGF-1 axis.

SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

This study shows that SARS-CoV-2 mRNA vaccines are re-adenylated in vivo, increasing antigen production and immune response in macrophages.

Tumoroscope: a probabilistic model for mapping cancer clones in tumor tissues

Tumoroscope maps cancer clones in tumor tissues by integrating spatial transcriptomics, whole exome sequencing, and pathological images to reveal spatial patterns and clone-specific gene expression.

Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells

This study shows that CD71+ erythroid cells (CECs) suppress T-cell responses through ARG and ROS mechanisms, but lose this ability as they differentiate into mature erythrocytes.

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells