Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition.
A. Datta, E. Sandilands, K. E. Mostov, D. M. Bryant
The paper shows fibroblast-derived HGF induces correct polarity and acinar morphogenesis in lung cancer cells by inhibiting RhoA-ROCK1 via integrin and c-Src signaling.
bioRxiv · Sep 6, 2017Cell Biology