Author

K. F. Medler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:transcription & RNA processing· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

A. E. Loats· 2 shared S. G. E. Roberts· 2 shared A. F. Fleming· 1 shared A. J. Moorhouse· 1 shared A. R. E. Roberts· 1 shared A. Sherrard· 1 shared E. Toska· 1 shared S. Carrera· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

A. E. Loats

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2 papers

Recent·Most cited

The BASP1 transcriptional repressor modifies chromatin through lipid-dependent and lipid-independent mechanisms

A. J. Moorhouse, A. E. Loats, K. F. Medler, S. G. E. Roberts

This study identifies lipid-dependent and lipid-independent mechanisms by which BASP1 modifies chromatin and represses transcription, with implications for its tumor suppressor function.

bioRxiv · Feb 15, 2022 · PreprintBiochemistry

Nuclear cholesterol is required for transcriptional repression by BASP1

A. E. Loats, S. Carrera, A. F. Fleming, A. R. E. Roberts, A. Sherrard, E. Toska, K. F. Medler, S. G. E. Roberts

This study shows that nuclear cholesterol is required for BASP1-mediated transcriptional repression by facilitating chromatin remodelling and gene-specific repression.

bioRxiv · Jan 24, 2021Biochemistry