Improved yield of AAV2 and rAAV2-retro serotypes following sugar supplementation during the viral production phase
M. Rego, L. M. Hanley, I. Ersing, K. Guerin, M. Tasissa, L. Haery, I. Mueller, E. Sanders, M. Fan
This study shows that adding sucrose or sorbitol during AAV production increases yields of AAV2 and rAAV2-retro serotypes by 1.8-fold and 1.5-fold, respectively, without affecting purity or infectivity.
bioRxiv · Dec 10, 2018 · PreprintCell Biology